Pangrol 10000 hard capsules with gastro-resistant coated skin, 200 pieces

Area of application

This medicine belongs to the group of pancreatic enzyme preparations.Pancreatic enzymes are digestive enzymes of the pancreas.The most important digestive enzymes are lipase, amylase and proteases.Lipase breaks down fat from food, amylase breaks down starch and protease breaks down protein.

The enzymes are in capsules with gastric acid-resistant microtablets.The microtablets are released from the capsules in the stomach and mix with the food so that the enzymes are distributed in the food and reach the small intestine.

It is used to replace digestive enzymes in cases of poor digestion (maldigestion) due to impaired pancreatic function.

The medicine is suitable for adults, teenagers and children.

No prescription is required for this product.

Active ingredients / ingredients / ingredients

106.5 mg pancreas powder (porcine)

10000 PhEur-E triacylglycerol lipase

Amylase

Proteases

Cellulose, microcrystalline excipient (+)

Quinoline yellow excipient (+)

Croscarmellose, sodium salt excipient (+)

Iron (III) hydroxide oxide x-water excipient (+)

Iron (III) oxide excipient (+)

Eudragit L 30 D-55 excipient (+)

Gelatin excipient (+)

Indigo carmine excipient (+)

Magnesium stearate (Ph. Eur.) [pflanzlich] excipient (+)

Castor oil, hydrogenated excipient (+)

Silicon dioxide, highly disperse auxiliary (+)

Simeticon Emulsion 30% excipient (+)

Talc excipient (+)

Titanium dioxide auxiliary (+)

Triethyl citrate excipient (+)

1 mmol total sodium ion excipient (+)

Total Sodium Ion Excipient (+)

Contraindications

This medicine must not be taken if you are allergic to pork pancreas powder or any of the other ingredients of this medicine.

If you are allergic to pork protein, you may also be allergic to this supplement because the pancreas powder it contains comes from the pancreas of pigs.

Dosage

Always take this medicine exactly as described or as directed by your doctor or pharmacist.Check with your doctor or pharmacist if you are unsure.

The dose must be adjusted individually and, taking into account the quantity and composition of meals, should not exceed the enzyme dose necessary for adequate fat digestion.The dose should only be increased under medical supervision and should be aimed at improving the symptoms of the disease (e.g. fatty stools, abdominal pain).

There are different strengths and dosage forms available: your doctor will recommend the dose that is most suitable for you.

The recommended dose for adults and adolescents is 20,000 to 75,000 units per meal (equivalent to 2 to 7 capsules) or 10,000 to 25,000 units per snack (equivalent to 1 to 2 capsules).Some patients require significantly higher dosages.

For infants and children, the recommended starting dose is 10,000 - 20,000 Ph. Eur. units per meal.

The maintenance dose is 500 to 4,000 units of lipase per gram of fat (equivalent to 50,000 to 100,000 units of lipase per day or 5 to 10 capsules of 10,000 units or 2 to 4 capsules of 25,000 per day).

The duration of use depends on the course of the disease.The preparation is suitable for long-term treatment.As long as the digestive weakness persists, continuous administration of the medication is necessary.

If you have taken more than you should and experience unwanted symptoms, talk to your doctor.

You can take the capsules up to half an hour after a meal.If you forget to take it, you may experience stomach upset after eating.Do not take double the amount at the next meal.

If you stop taking it, the symptoms may recur.If you have any problems that could lead to discontinuation of treatment, please speak to your doctor.

If you have any further questions about using the medicine, contact your doctor or pharmacist.

Intake

Take the preparation with meals with plenty of liquid, such as fruit juice.

If you cannot swallow the capsules whole, you can open the capsules by pulling them apart and mixing the contents with a small amount of liquid or soft food (such as orange juice, apple juice or applesauce) that you can swallow without chewing.Swallow this immediately after mixing and without chewing.Drink a glass of water or juice afterwards to ensure all the medicine is washed down.

Do not mix the capsule contents with alkaline foods or drinks such as milk, ice cream or tea.Neither the capsules nor their contents should be chewed.

Patient information

Please talk to your doctor or pharmacist before taking this medicine. If these active enzymes are not taken as directed, they can irritate the mucous membrane in the oral cavity if they are released there.Therefore, the capsules and/or their contents must be swallowed whole without chewing.

When taking high doses, the uric acid concentration in the urine should be monitored.

If you have cystic fibrosis (a hereditary disease that affects several organs, but mainly the lungs and the digestive system) and need to be treated with high doses, in this particular case you may experience narrowing of the colon.

The medicine has no effect on the ability to drive or use machines.

Pregnancy

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

This medicine can be taken during pregnancy or breastfeeding.As far as is known, there is no risk to the fetus or baby.However, you must strictly adhere to the prescribed dose.

If you take vitamin B11 (folic acid) during pregnancy, you may need to take a higher dose of folic acid.In this case, please speak to your doctor first.

Notes

For information about risks and side effects, read the package leaflet and ask your doctor or pharmacy.

Other

Care must be taken to swallow the preparation whole, as it contains active enzymes that, when released into the oral cavity, e.g.B. by chewing, which can lead to damage to the mucous membrane (ulcerations of the oral mucosa).

The absorption of folic acid (absorption of folic acid into the blood) can be reduced by taking finished medicines containing pancreas powder, so additional folic acid intake may be necessary.

The effect of the blood sugar-lowering active ingredients (oral antidiabetics) acarbose and miglitol can be reduced by taking the preparation at the same time.

In individual cases, allergic reactions of the immediate type (such as skin rash, sneezing, lacrimation, bronchospasm) as well as allergic reactions of the digestive tract have been described after taking pancreas powder.If this allergic reaction occurs, the preparation must be stopped immediately and a doctor must be consulted as soon as possible.

In patients with a characteristic malfunction of the pancreas (cystic fibrosis), the formation of narrowings (strictures) in the lower sections of the intestine (ileocecal region and ascending colon) has been described in individual cases after administration of high doses of pancreas powder.

For intestinal obstruction-like symptoms.Intestinal obstruction is a known complication in patients with cystic fibrosis.If symptoms similar to intestinal obstruction are present, the possibility of intestinal strictures should also be taken into account.

In patients with cystic fibrosis, increased uric acid excretion in the urine may occur, especially when taking high doses of pancreatin.Therefore, uric acid excretion in the urine should be controlled in these patients to avoid the formation of uric acid stones.

The preparation must not be taken in acute pancreatitis or an acute attack of chronic pancreatitis during the florid phase of the disease.

Application

The dosage depends on the severity of the pancreatic insufficiency.As a general guideline dose, a lipase content of 20,000-40,000 per meal is recommended FIP.

Unless otherwise prescribed, the dose is 2-4 capsules per meal.

Ingredients

1 gastro-resistant hard capsule contains: Pig pancreas powder 118.1 mg.(Lipase activity 10000 FIP, amylase activity 9000 FIP, protease activity 500FIP)

Other ingredients: hydrogenated castor oil, colloidal silicon dioxide, magnesium stearate, croscarmelose sodium, microcrystalline cellulose, methacylic acid-ethyl acrylate copolymer, talc, triethyl citrate, simeticone emulsion, macrogol stearate, macrogol, xanthan gum, triglycerides, benzoic acid, glycerin, sodium chloride, octamethylcyclotetrasiloxane,Sorbic acid, sulfuric acid, purified water, iron-III-osic, iron-III-hydroxide oxide, indigo carmine, quinoline yellow, titanium dioxide, gelatin.