Pangrol 25000 hard capsules with gastro-resistant coated skin, 200 pieces

Application

Pangrol is used to replace digestive enzymes in digestive disorders caused by inadequate or missing pancreatic function.It contains digestive enzymes from the pancreas, also called pancreatic enzymes.

Area of application

The preparation contains digestive substances, namely enzymes from the pancreas of pigs, which are called pancreas powder or pancreatin.It is used to treat digestive disorders caused by reduced or absent pancreatic function.

Active ingredients / ingredients / ingredients

An enteric-coated hard capsule contains porcine pancreas powder with a lipase activity of 25,000 Ph.Eur. units, amylase activity of 22,500 Ph.Eur. units and protease activity of 1,250 Ph.Eur. units.In addition, the capsule contains the following excipients: hydrogenated castor oil, colloidal silicon dioxide, magnesium stearate, croscarmellose sodium, microcrystalline cellulose, methacrylic acid-ethyl acrylate copolymer, talc, triethyl citrate, simeticone emulsion, iron (III) oxide, iron (III) hydroxide oxide, indigo carmine, quinoline yellow, titanium dioxide, gelatin and sodium chloride.

Contraindications

This medicine must not be taken if you are allergic to pancreas powder, pork or any of the other ingredients of this medicine.It is also not permitted to be taken in the event of acute inflammation of the pancreas or an acute attack of chronic inflammation of the pancreas during the fully developed phase of the disease.However, in the decline phase during the dietary build-up, it may occasionally make sense to take it.

Dosage

Always take this medicine exactly as your doctor has told you.The recommended dose is 1 capsule per meal, which corresponds to 25,000 Ph.Eur. units of lipase per meal.The dosage depends on the severity of the indigestion and may therefore be higher.The dose should only be increased under medical supervision and should be aimed at improving the symptoms of the disease.A daily enzyme dose of 15,000 to 20,000 units of lipase per kilogram of body weight should not be exceeded.Especially in patients with cystic fibrosis, the enzyme dose should not be higher than necessary for adequate fat absorption.The doctor should decide on the dosage for children.

The duration of use is not subject to any restrictions and depends on the course of the disease, which is determined by the doctor.If you don't feel better or even feel worse, contact your doctor.Please talk to your doctor or pharmacist if you have the impression that the effect is too strong or too weak.

If you take more than you should, drink plenty of water and talk to your doctor or pharmacist.Repeated high doses of pancreas powder can cause scarring or thickening of the intestinal wall, which can lead to blockage of the intestine, a condition called fibrosing colonopathy.Extremely high doses of pancreas powder can lead to an increase in uric acid in the blood and urine, especially in cystic fibrosis patients.

If you forget to take a dose, do not take a double dose, but please continue treatment as recommended.If you stop taking it, you should expect that your symptoms may return.Please consult your doctor.

If you have any further questions about using the medicine, contact your doctor or pharmacist.

Intake

Take the capsule whole without chewing with sufficient liquid, preferably in the middle of the meal.If you have difficulty swallowing the capsule whole, you can carefully open it over a suitable container by pulling it apart and swallow just the contents with a little liquid immediately and without chewing.Please make sure that you do not crush or chew the capsules or their contents, otherwise the medicine will lose its effectiveness and the enzymes it contains can damage the mucous membrane if released into the oral cavity.You should drink plenty of fluids (water or juice).

Patient information

Please talk to your doctor or pharmacist before taking the medicine, especially if you suffer from cystic fibrosis and take more than 10,000 Ph.Eur. units of lipase per kilogram of body weight per day.Tell your doctor if you notice any unusual abdominal discomfort or changes in abdominal symptoms.If you have an allergic reaction, stop treatment and talk to your doctor. This medicine contains active enzymes which, when released into the mouth, can cause damage to the oral mucosa.Be sure to swallow the capsules whole.

The medicine has no or negligible influence on the ability to drive and use machines.

Pregnancy

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using any medicines.There is insufficient experience with the use of the drug in pregnant women.If you are pregnant or breast-feeding, you should not take this medicine unless your doctor considers it absolutely necessary.

Notes

No prescription is required for this product.Care must be taken to swallow the preparation whole, as it contains active enzymes that can cause damage to the mucous membrane when released into the oral cavity.The absorption of folic acid can be reduced by taking finished medicines containing pancreas powder, so additional folic acid intake may be necessary.The effect of the blood sugar-lowering active ingredients acarbose and miglitol can be reduced by taking the preparation at the same time.Allergic reactions have been described in individual cases.If this allergic reaction occurs, the preparation must be stopped immediately and a doctor must be consulted as soon as possible.In patients with cystic fibrosis, the formation of narrowings in the lower sections of the intestine has been described in individual cases after administration of high doses of pancreas powder.If symptoms are similar to intestinal obstruction, the possibility of intestinal strictures should also be taken into account.In patients with cystic fibrosis, increased uric acid excretion in the urine may occur, especially when taking high doses of pancreatin.Therefore, uric acid excretion in the urine should be controlled in these patients to avoid the formation of uric acid stones.The preparation must not be taken in acute pancreatitis or an acute attack of chronic pancreatitis during the florid phase of the disease.